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A patient diagnosed with Lupus was given a death sentence by a doctor. It is not necessary to pass a death sentence because of an autoimmune disease like lupus or even cancer. The ancient folk medicine practitioners have been using Sorghum bicolor Leaf Sheaths as decoction tea to treat chronic diseases like arthritis, infertility, heart disease, diabetes, sickle cell anaemia and even cancer. Modern science has revealed that this plant has the highest concentration of Polyphenols. Polyphenols possess a wide-range of pharmacological and therapeutic properties, including antioxidant and anti-inflammatory activities. As immunomodulatory agents, polyphenols are emerging pharmaceutical tools for management of various autoimmune disorders including vitiligo, ulcerative colitis and multiple sclerosis (MS). Polyphenols activate intracellular pathways such as arachidonic acid dependent pathway, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signalling pathway, mitogen-activated protein kinases (MAPKs) pathway, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway and epigenetic modulation, which regulate the host’s immune response. A recent review discusses putative points of action of polyphenols in autoimmune diseases, characterizing their efficacy and safety as therapeutic agents in managing autoimmune disorders. Recently, the National Cancer Institute listed Sorghum bicolor supplement Jobelyn made from Sorghum bicolor leaf sheaths in its drug dictionary and described it as being rich in Polyphenols and phenolic acids with the potential for antioxidant, anti-inflammatory, chemopreventive and immunomodulating capabilities. To learn more about the uniqueness of this ancient herb please click:

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